TDC podcast Dr. Mark Lysyshyn

TDC Podcast 11 – Dr. Mark Lysyshyn on Fentanyl Drug Checking, Supervised Consumption Facilities & More

Dr. Mark Lysyshyn is a medical health officer with Vancouver Coastal Health in British Columbia, Canada. The Vancouver region, like many parts of North America, has been strongly affected by the rise in opioid-related fatalities. Dr. Lysyshyn is among those working to reduce fatalities by researching and expanding harm reduction tools. He recently co-authored a […]

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TDC Podcast Brad Burge

TDC Podcast 10 – Brad Burge on MAPS’ Psychedelic Research, MDMA Therapy, & More

Brad Burge is the Director of Communications at the Multidisciplinary Association for Psychedelic Studies (MAPS). MAPS is a leading organization in the field of psychedelic research and it has been particularly focused on MDMA-assisted psychotherapy, largely for PTSD. MDMA appears to be very useful in the treatment of PTSD. A couple therapy sessions with the […]

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Overview: The Most and Least Effective Antidepressants

Summary: 522 randomized controlled trials involving 21 antidepressants and 116,477 people were analyzed. It appears the most effective antidepressants (at a duration of 8 weeks) include amitriptyline, escitalopram, mirtazapine, paroxetine, and venlafaxine. While reboxetine and trazodone had notably lower efficacy ratings. Some of the most effective drugs had lower tolerability scores, however, indicating they may […]

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Guy Jones

TDC Podcast 9 – Guy Jones on Drug Checking, Research Chemicals, & More

Guy Jones runs Reagent Tests UK and is a senior chemist for The Loop, a drug checking organization in the UK. He’s also associated with Kosmicaid, a group that offers psychedelic harm reduction services at music events. Drug checking involves analyzing a substance with tools like reagent liquids and GC/MS in order to gain a […]

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Lyn Ulbricht - Silk Road - Ross Ulbricht

TDC Podcast 8 – Lyn Ulbricht on The Silk Road Case, Injustice In The Justice System, & More

Ross Ulbricht, the founder of Silk Road, an online Bitcoin-based marketplace, was arrested in 2013. The authorities primarily targeted him due to the actions of Silk Road’s users, who frequently utilized the site for drug transactions. Ulbricht was eventually sentenced to life in prison, highlighting potentially severe problems in the justice system. The case touches […]

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Overview: The Post-Acute Brain Activity Changes Of Psilocybin For Treatment-Resistant Depression

TDC abstract: Psilocybin, a prodrug for psilocin, appears to have detectable effects on brain activity the day after an experience in those with treatment-resistant depression. There’s a rise in functional connectivity within the default mode network (DMN) and a decline in functional connectivity between the parahippocampus and prefrontal cortex. Authors: Robin L Carhart-Harris, Leor Roseman, Mark […]

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TDC Podcast 7 – Christopher Moraff on The “Opioid Epidemic,” Philadelphia’s Drug Market & More

Christopher Moraff is a journalist based in Philadelphia, Pennsylvania. He’s covered the drug war and the regional impact of drug prohibition. He writes for The Daily Beast,, and The Crime Report. In this episode we discuss fentanyl’s impact on the Philadelphia drug market, prohibition, the “opioid epidemic,” and local policies, among other things. Twitter […]

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TDC Podcast 6 – Dr. David Juurlink on Opioid Risks, Problematic Prescribing & More

David Juurlink is a physician, pharmacologist, and drug safety researcher. He’s affiliated with the Institute for Clinical Evaluative Sciences (ICES), the University of Toronto, Sunnybrook Research Institute, and Sunnybrook Health Sciences Centre. Though he deals with many drug classes in his daily work, his perspectives on opioid prescribing and the “opioid epidemic” in particular have received a […]

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TDC Podcast 5 – Julian Buchanan on the Global Drug Policy Problem

Julian Buchanan has worked in the area of drug policy reform and education for decades. Initially a social worker/probation officer, he eventually become a professor. During the course of his teaching career, Buchanan worked at Liverpool University, University of Central Lancashire, Glyndwr University, and Victoria University of Wellington. He was a Consultant and Independent Expert […]

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TDC Podcast 4 – Adam from PsychedSubstance on Psychedelic Harm Reduction, Philosophy & More

Adam is the founder of two popular YouTube channels, PsychedSubstance and SWIM. He’s had an interest in drugs, most notably psychedelics and entactogens, for years. He offers entertaining content about various substances. Although he’s been focused on psychedelics since PsychedSubstance began, he’s also covered non-psychedelics to some extent. We talk about psychedelic harm reduction, philosophy, […]

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TDC Podcast 3 – Glen Carner, LMHC on Addiction, Alternatives to Abstinence & More

Glen Carner is a psychotherapist focused on addiction. He received an MA from Fairleigh Dickinson University and is a Licensed Mental Health Counselor (LMHC). Along with working in the field of addiction treatment, Glen offers family therapy. His practice, Family & Addiction Counseling, has locations in Honolulu and Kapolei, Hawaii. You can find more about […]

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Overview: Placebo Stimulants Make You Think You’re Performing Better

TDC abstract: Placebo stimulants are capable of increasing self-reported alertness, focus, and positive mood. These effects are present in the absence of neuropsychological improvement, demonstrating a placebo, likely due to positive expectancies, can make users believe they’re receiving a benefit. Authors: Samantha Lookatch, Hayley Fivecoat, and Todd Moore DOI: 10.1080/02791072.2017.1344897 Link: Published: July 2017 Background The level of nonmedical […]

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