LSD microdosing study

Overview: Controlled Trial of LSD Microdosing Reveals Modest Effects

Summary: LSD microdoses (13 μg and 26 μg) changed psychological and behavioral functioning, but the effects were relatively modest and many areas of functioning were not altered at all. Microdosing did not have a positive effect on cognitive performance. Authors: Anya K. Bershad, Scott T. Schepers, Michael P. Bremmer, Royce Lee, Harriet de Wit DOI: 10.1016/j.biopsych.2019.05.019 […]

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Dr. Rick Barnett

TDC Podcast 14 – Dr. Rick Barnett on Addiction Treatment and Why Psychologists Should Be Prescribers

Dr. Rick Barnett is a psychologist with a doctorate in psychology and a master’s degree in clinical psychopharmacology. He owns a private mental health practice in Vermont called BPS Health, LLC and is also President-Elect of the American Psychology Association’s Division 55 (American Society for the Advancement of Pharmacotherapy). He is currently advocating in support […]

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Zach Rhoads

TDC Podcast 13 – Zach Rhoads on Outgrowing Addiction

Zach Rhoads is a counselor who works with families and children. Along with the psychologist Stanton Peele he has coauthored Outgrowing Addiction, a new book that explains why a developmental model of the disorder makes more sense than the disease model. The book draws on Zach’s personal experience with addiction and on his work with […]

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Hamilton Morris

TDC Podcast 12 – Hamilton Morris on the Expansive World of Drugs

Hamilton Morris is a journalist and scientific researcher known for his documentaries, particularly those in the series Hamilton’s Pharmacopeia, which is available through iTunes, Google Play, Hulu, and more. He has also written a number of articles for Harpers, which can be found here: In this episode we cover a range of topics, from sacred […]

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TDC podcast Dr. Mark Lysyshyn

TDC Podcast 11 – Dr. Mark Lysyshyn on Fentanyl Drug Checking, Supervised Consumption Facilities & More

Dr. Mark Lysyshyn is a medical health officer with Vancouver Coastal Health in British Columbia, Canada. The Vancouver region, like many parts of North America, has been strongly affected by the rise in opioid-related fatalities. Dr. Lysyshyn is among those working to reduce fatalities by researching and expanding harm reduction tools. He recently co-authored a […]

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TDC Podcast Brad Burge

TDC Podcast 10 – Brad Burge on MAPS’ Psychedelic Research, MDMA Therapy, & More

Brad Burge is the Director of Communications at the Multidisciplinary Association for Psychedelic Studies (MAPS). MAPS is a leading organization in the field of psychedelic research and it has been particularly focused on MDMA-assisted psychotherapy, largely for PTSD. MDMA appears to be very useful in the treatment of PTSD. A couple therapy sessions with the […]

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Overview: The Most and Least Effective Antidepressants

Summary: 522 randomized controlled trials involving 21 antidepressants and 116,477 people were analyzed. It appears the most effective antidepressants (at a duration of 8 weeks) include amitriptyline, escitalopram, mirtazapine, paroxetine, and venlafaxine. While reboxetine and trazodone had notably lower efficacy ratings. Some of the most effective drugs had lower tolerability scores, however, indicating they may […]

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Guy Jones

TDC Podcast 9 – Guy Jones on Drug Checking, Research Chemicals, & More

Guy Jones runs Reagent Tests UK and is a senior chemist for The Loop, a drug checking organization in the UK. He’s also associated with Kosmicaid, a group that offers psychedelic harm reduction services at music events. Drug checking involves analyzing a substance with tools like reagent liquids and GC/MS in order to gain a […]

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Lyn Ulbricht - Silk Road - Ross Ulbricht

TDC Podcast 8 – Lyn Ulbricht on The Silk Road Case, Injustice In The Justice System, & More

Ross Ulbricht, the founder of Silk Road, an online Bitcoin-based marketplace, was arrested in 2013. The authorities primarily targeted him due to the actions of Silk Road’s users, who frequently utilized the site for drug transactions. Ulbricht was eventually sentenced to life in prison, highlighting potentially severe problems in the justice system. The case touches […]

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Overview: The Post-Acute Brain Activity Changes Of Psilocybin For Treatment-Resistant Depression

TDC abstract: Psilocybin, a prodrug for psilocin, appears to have detectable effects on brain activity the day after an experience in those with treatment-resistant depression. There’s a rise in functional connectivity within the default mode network (DMN) and a decline in functional connectivity between the parahippocampus and prefrontal cortex. Authors: Robin L Carhart-Harris, Leor Roseman, Mark […]

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TDC Podcast 7 – Christopher Moraff on The “Opioid Epidemic,” Philadelphia’s Drug Market & More

Christopher Moraff is a journalist based in Philadelphia, Pennsylvania. He’s covered the drug war and the regional impact of drug prohibition. He writes for The Daily Beast,, and The Crime Report. In this episode we discuss fentanyl’s impact on the Philadelphia drug market, prohibition, the “opioid epidemic,” and local policies, among other things. Twitter […]

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TDC Podcast 6 – Dr. David Juurlink on Opioid Risks, Problematic Prescribing & More

David Juurlink is a physician, pharmacologist, and drug safety researcher. He’s affiliated with the Institute for Clinical Evaluative Sciences (ICES), the University of Toronto, Sunnybrook Research Institute, and Sunnybrook Health Sciences Centre. Though he deals with many drug classes in his daily work, his perspectives on opioid prescribing and the “opioid epidemic” in particular have received a […]

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