Selegiline is an MAO enzyme inhibitor that preferentially inhibits MAO-B at the doses commonly used. In medical settings, it is used for Parkinson’s disease and depression. It’s been investigated for other conditions.
The drug is largely void of recreational effects, but it can anecdotally increase motivation and provide some mood improvement. Selegiline is sometimes taken for its potential nootropic and life extension properties.
At common doses, the substance functions by altering dopamine and phenethylamine activity.
Selegiline = Deprenyl; L-deprenyl; (R)-9CI; (-)-Deprenyl; R-Deprenyl; E-250; N,a-Dimethyl-N-2-propynyl; (R)-N-methyl-N-(1-phenylpropan-2-yl)prop-1-yn-3-amine
Parkinson’s: 10 mg
Depression: 30 – 60 mg/day
Parkinson’s: 1.25 mg
Total: 6 – 12 mg/day
Common: 5 – 10 mg
Full range: 1 mg – 10 mg
Subjective: Possibly greatest during the first few hours
Total: Inexact, 24+ hours for MAO inhibition (once daily dosing is used)
(1996) Pharmacology of selegiline.