Mirtazapine

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Mirtazapine is a tetracyclic antidepressant in the NaSSA class. It has a similar efficacy to SSRIs and TCAs, and it may be a better option for certain populations.

The drug may have some efficacy for other conditions like PTSD, anxiety, panic disorder, insomnia, and OCD. More research is needed in those areas.

Unlike some antidepressants, mirtazapine usually doesn’t cause sexual dysfunction and it doesn’t impair sleep. It often increases sleep, reduces sleep latency, and boosts slow-wave sleep.

Some recreational effects like euphoria, CEVs, enhancement of cannabis, and dream enhancement have been reported at certain doses. It’s not clear how reliable those effects are.


Mirtazapine: Remeron; Avanza; Zispin


Dose

Oral (Medical)

Range: 15 – 45 mg

Oral (Recreational)

Light: 50 – 100 mg

Common: 100 – 200 mg

Strong: 200+ mg


Timeline

Oral

Total: 4 – 10 hours (therapeutic effects can last an entire day)

Onset: ~00:30


Experience Reports

Erowid



References

(2014) Reduction of parkinsonism and psychosis with mirtazapine: a case report.

(2011) Mirtazapine versus other antidepressive agents for depression.

(2011) Review of the use of mirtazapine in the treatment of depression.

(2011) Multi-drug Overdose Induced Seizure Associated with Mirtazapine

(2009) Mirtazapine: a review of its use in major depression and other psychiatric disorders.

(2008) Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.

(2007) Lack of significant toxicity after mirtazapine overdose: a five-year review of cases admitted to a regional toxicology unit.

(2006) Therapeutic and toxic concentrations of mirtazapine.

(2005) Non-lethal mirtazapine overdose with rhabdomyolysis.

(2003) Mirtazapine vs. placebo in posttraumatic stress disorder: a pilot trial.

(2002) Severe serotonin syndrome induced by mirtazapine monotherapy.

(2002) The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms.

(2001) A review of the pharmacological and clinical profile of mirtazapine.

(2000) Clinical pharmacokinetics of mirtazapine.

(1999) Mirtazapine: a review of its use in major depression.

(1999) Efficacy and tolerability of mirtazapine versus citalopram: a double-blind, randomized study in patients with major depressive disorder.

(1999) Distribution of mirtazapine (Remeron) in thirteen postmortem cases.

(1998) Suicide attempts with mirtazapine overdose without complications.

(1997) Mirtazapine: pharmacology in relation to adverse effects.

(1995) Clinical efficacy of mirtazapine: a review of meta-analyses of pooled data.

(1995) The effects of mirtazapine on central noradrenergic and serotonergic neurotransmission.

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