JWH-250

3816

JWH-250 StructureJWH-250 is a synthetic cannabinoid receptor agonist that has been detected in products since the late 2000s. It was created by Dr. John W. Huffman and a report on it was released in 2005 by Huffman et al.

The drug is a phenylacetylindole and it works as an agonist at CB1 and CB2 receptors. It has an affinity of ~11 nM at CB1 and ~33 nM at CB2.

A few years after it was first mentioned in the literature, JWH-250 appeared on the market, with the first detection coming from German police in May 2009. They found the drug in an herbal smoking mixture.

It’s also been detected in powders and blends sold via the internet to researchers in Japan. Those samples contained 77-165 mg per product.

Because of the way it’s been sold, it’s likely people have encountered JWH-250 without realizing it.


JWH-250 = 1-pentyl-3-(2-methoxyphenylacetyl)indole


Dose

Not currently available due to a lack of information.


Timeline

Not currently available due to a lack of information.


Experience Reports

Erowid



References

(2013) Validation of a Novel Immunoassay for the Detection of Synthetic Cannabinoids and Metabolites in Urine Specimens

(2012) Identification of the major urinary metabolites in man of seven synthetic cannabinoids of the aminoalkylindole type present as adulterants in ‘herbal mixtures’ using LC-MS/MS techniques

(2011) Gas and liquid chromatography–mass spectrometry studies on the metabolism of the synthetic phenylacetylindole cannabimimetic JWH-250, the psychoactive component of smoking mixtures

(2010) Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylindoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products

(2010) Identification and quantitation of cannabimimetic compound JWH-250 as an adulterant in products obtained via the Internet

(2010) Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds

(2005) 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles

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