GHB is a depressant which can be found naturally in the human body. It is used in recreational settings for its disinhibiting, libido-enhancing, pro-social, and sedative effects. The drug has also been used medically in people with narcolepsy and it was once widely used by bodybuilders for its positive effects on growth hormone levels.

Dose greatly affects the substance’s effects, with experiences ranging from moderate relaxation and greater sociability to overwhelming sedation and unconsciousness.

When common amounts are used, the drug isn’t particularly dangerous for healthy people acutely. Issues can arise with combinations (particularly with other depressants), high doses, and heavy frequent use.

GHB = G; Xyrem; Sodium Oxybate; gamma-Hydroxybutyric acid; γ-Hydroxybutyric acid



Light: 0.5 – 1.5 grams

Common: 1 – 2.5 grams

Strong: 2.5+ grams



Total: 1.5 – 2.5 hours (strong+ doses can last longer)

Onset: 00:10 – 00:20

Experience Reports



(2012) The clinical toxicology of γ-hydroxybutyrate, γ-butyrolactone and 1,4-butanediol.

(2012) Reconsidering GHB: orphan drug or new model antidepressant?

(2011) GHB and synthetic cathinones: clinical effects and potential consequences.

(2009) A multi-drug intoxication fatality involving Xyrem (GHB).

(2009) Identification of GHB and morphine in hair in a case of drug-facilitated sexual assault

(2009) Ketamine and GHB: New trends in club drug use?

(2008) GHB and its precursor GBL: an emerging trend case study

(2007) Prevalence of gamma-hydroxybutyrate (GHB) in serum samples of amphetamine, metamphetamine and ecstasy impaired drivers.

(2006) Trends in gamma-hydroxybutyrate (GHB) and related drug intoxication: 1999 to 2003.

(2004) From the street to the brain: neurobiology of the recreational drug γ-hydroxybutyric acid

(2004) Fatalities associated with the use of γ-hydroxybutyrate and its analogues in Australasia

(2004) Adolescent gamma-hydroxybutyric acid exposure decreases cortical N-methyl-D-aspartate receptor and impairs spatial learning.

(2002) GHB use among Australians: characteristics, use patterns and associated harm.

(2002) Trends in illicit drug emergencies: the emerging role of gamma-hydroxybutyrate.

(2001) Suspicious death related to gamma-hydroxybutyrate (GHB) toxicity

(2001) GHB: a new and novel drug of abuse.

(2000) A novel method for GHB detection in urine and its application in drug-facilitated sexual assaults.

(1999) The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies.

(1998) Gamma-hydroxybutyric acid: an emerging recreational drug.

(1998) GHB-induced delirium: a case report and review of the literature of gamma hydroxybutyric acid.

(1997) Sites of action of gamma-hydroxybutyrate (GHB)–a neuroactive drug with abuse potential.

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  • Tameka

    While GHB is known for being the date rape drug and being dangerous it surprisingly also has benefits for those with Fibromyalgia. It is also highly addictive which is why I’ve been on a search to research it.

    Should anyone else be interested to see how this would help others here’s the page I looked at

    Hopefully, this information can provide more insight on the drug that someone may not know about as it is a very complex drug.