Diphenhydramine (DPH, Benadryl)


Diphenhydramine is an antihistamine and anticholinergic which is commonly used to combat allergies, insomnia, and cold symptoms. Once you move beyond the recommended dose range, it can have strong sedating and deliriant effects.

Those sedating and deliriant effects have led to its use as a recreational drug. However, the delirium it produces is almost always unpleasant .

At sub-deliriant doses, it can act as a sedative on its own and it can also potentiate the effects of other depressants.

Diphenhydramine = DPH; Benadryl; Nytol



Insomnia: 50 mg

Light: 150 – 250 mg

Common: 250 – 500 mg

Strong: 500 – 650 mg



Total: 6 – 8 hours

Onset: 01:00 – 02:00

After: There may be lingering effects which persist for up to 24 hours after administration.

Experience Reports


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  • Erwan Leubreuton

    hi! sorry, maybe is it an mistacke of me but why is the molecular structur of serotonin that we see under “anticholinergic & antihistaminic” (02:07)?
    Great idea to make this chain, you had problem with your youtube channel? what happened?

    • I hadn’t noticed that mistake until now, thanks for pointing it out. The serotonin molecule in that part isn’t relevant, I must have inserted it instead of the DPH molecule by accident and never noticed.

      The channel was terminated by YouTube. I’m still waiting to hear back about the reason given it’s quite odd to have the channel removed.

      This site should be a better resource though regardless.

      • Erwan Leubreuton

        ok, i was thinking that it was related to the inhibit the reuptake of 5HT^^. I hope is not about your subject, I am thinking to make channel on this theme in french language (not a copy of course but in same idea), maybe with more exposed historique aspect or character but it is still an idea, I’ll see if it can bring something.

  • Erwan Leubreuton

    Lol, sorry I have to wait to see the end of the video. as much for me! 😉

  • Fuck this drug, man