Buprenorphine is a semisynthetic thebaine derivative in the orvinol class. It’s an opioid that’s widely used for pain and opioid replacement. While it does provide recreational effects, users reliably prefer opioids like morphine.
It has a similar efficacy to methadone in the area of opioid replacement.
The risk of death from overdose is lower with buprenorphine due to it producing less respiratory depression. It can still be very dangerous when combine with other depressants like benzodiazepines and alcohol.
Buprenorphine = Subutex; Buprenex; Temgesic; Cizdol; Butrans; Norspan
Light: 1 – 2 mg
Common: 3 – 6 mg
Strong: 6 – 8+ mg
Total: 8 – 12 hours (up to 24 hours or more with strong+ doses)
Onset: 00:30 – 01:00
(2003) Analgesic efficacy and tolerability of transdermal buprenorphine in patients with inadequately controlled chronic pain related to cancer and other disorders: a multicenter, randomized, double-blind, placebo-controlled trial.